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pentobarbital will lessen the extent or outcome of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; keep away from use in sufferers who're chronically using a strong CYP3A4 inducerpentobarbital will decrease the level or impact of